Search results for " anti-HIV-1 activity"

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A QSAR study investigating the potential anti-HIV-1 effect of some acyclovir and ganciclovir analogs

2009

A QSAR study, involving the use of calculated physical-chemical properties (TSAR TM ), and the use of a neural network approach (TSAR TM ), has been performed on the potential anti-HIV-1 activity of a series of Acyclovir and Ganciclovir analogs. Model obtained allows reliable predictions for the anti-HIV-1 activity of these derivatives, and showed that the presence of the Ganciclovir chain in triazolopyrrolopyrimidine and pyrimidopyrrolopyrimidine series seems to increase the antiviral effect.

GanciclovirAnti hiv 1Quantitative structure–activity relationshipStereochemistryChemistryOrganic ChemistrymedicineQSAR neural network BMLR anti-HIV-1 activityvirus diseasesPharmacologySettore CHIM/08 - Chimica Farmaceuticamedicine.drug
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